Myocardial ischemia-reperfusion enhances transcriptional expression of endothelin-1 and vasoconstrictor ETB receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat.
Gry Freja SkovstedLars Schack KruseLukas Adrian BerchtoldAnne-Sofie GrellKarin WarfvingeLars EdvinssonPublished in: PloS one (2017)
These findings suggest that the MEK-ERK1/2 signaling pathway is important for regulating endothelin-1 and ETB receptors in myocardium and coronary arteries after ischemia-reperfusion in the ischemic region. Inhibition of the MEK-ERK1/2 pathway may provide a novel target for reducing ischemia-reperfusion damage in the heart.
Keyphrases
- pi k akt
- signaling pathway
- cell proliferation
- protein kinase
- induced apoptosis
- oxidative stress
- epithelial mesenchymal transition
- poor prognosis
- coronary artery
- coronary artery disease
- left ventricular
- heart failure
- gene expression
- atrial fibrillation
- transcription factor
- heat shock
- brain injury
- endoplasmic reticulum stress