Velcrin molecular glues induce apoptosis in glioblastomas with high PDE3A and SLFN12 expression.
Elisa AquilantiSilvia GoldoniAndrew BakerKristyna KotynkovaSawyer AndersenVincent BozinovGalen F GaoAndrew D CherniackMartin LangeRalf LescheCharlotte KopitzPhilip LienauTimothy A LewisMarine GarridoStefan GradlHenrik SeidelYuen-Yi TsengKeith L LigonPatrick Y WenMatthew MeyersonHeidi GreulichPublished in: Neuro-oncology advances (2024)
Velcrins have antitumor activity in preclinical models of glioblastoma, warranting further investigation as potential therapeutic agents.