Velcrin molecular glues induce apoptosis in glioblastomas with high PDE3A and SLFN12 expression.

Elisa AquilantiSilvia GoldoniAndrew BakerKristyna KotynkovaSawyer AndersenVincent BozinovGalen F GaoAndrew D CherniackMartin LangeRalf LescheCharlotte KopitzPhilip LienauTimothy A LewisMarine GarridoStefan GradlHenrik SeidelYuen-Yi TsengKeith L LigonPatrick Y WenMatthew MeyersonHeidi Greulich

Published in: Neuro-oncology advances (2024)

Velcrins have antitumor activity in preclinical models of glioblastoma, warranting further investigation as potential therapeutic agents.

Keyphrases

poor prognosis
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
cell death
cell therapy
stem cells
mesenchymal stem cells