Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network.
Matei BolboreaEric PollatzekHeather BenfordTamara Sotelo-HitschfeldNicholas DalePublished in: Proceedings of the National Academy of Sciences of the United States of America (2020)
Hypothalamic tanycytes are chemosensitive glial cells that contact the cerebrospinal fluid in the third ventricle and send processes into the hypothalamic parenchyma. To test whether they can activate neurons of the arcuate nucleus, we targeted expression of a Ca2+-permeable channelrhodopsin (CatCh) specifically to tanycytes. Activation of tanycytes ex vivo depolarized orexigenic (neuropeptide Y/agouti-related protein; NPY/AgRP) and anorexigenic (proopiomelanocortin; POMC) neurons via an ATP-dependent mechanism. In vivo, activation of tanycytes triggered acute hyperphagia only in the fed state during the inactive phase of the light-dark cycle.
Keyphrases
- liver failure
- cerebrospinal fluid
- respiratory failure
- spinal cord
- induced apoptosis
- poor prognosis
- drug induced
- pulmonary hypertension
- cell cycle arrest
- mitral valve
- hepatitis b virus
- pulmonary artery
- spinal cord injury
- signaling pathway
- drug delivery
- cell proliferation
- pulmonary arterial hypertension
- mechanical ventilation