Predictive modeling of COPD exacerbation rates using baseline risk factors.
Dave SinghJohn R HurstFernando J MartinezKlaus Friedrich RabeMona BafadhelMartin JenkinsDomingo SalazarPaul DorinskyPatrick DarkenPublished in: Therapeutic advances in respiratory disease (2022)
These models predicting rates of moderate/severe exacerbations can be applied to a broad range of patients with COPD in terms of airway obstruction, eosinophil counts, exacerbation history, symptoms, and treatment history. Understanding the relative and absolute risks related to these factors may be useful for clinicians in evaluating the benefit: risk ratio of various treatment decisions for individual patients.Clinical trials registered with www.clinicaltrials.gov (NCT02465567, NCT02497001, NCT02766608, NCT02727660, NCT01854645, NCT01854658, NCT02343458, NCT03262012, NCT02536508, and NCT01970878).
Keyphrases
- chronic obstructive pulmonary disease
- clinical trial
- risk factors
- end stage renal disease
- lung function
- ejection fraction
- randomized controlled trial
- palliative care
- newly diagnosed
- peritoneal dialysis
- intensive care unit
- physical activity
- combination therapy
- study protocol
- climate change
- drug induced
- phase ii
- acute respiratory distress syndrome
- patient reported outcomes