Imbalance of growth factors mRNA expression associated with oxidative stress in the early pregnancy loss.
Aspasia GalaziouEirini FilidouMichail SpathakisKonstantinos ArvanitidisBourazan Chalil ArzouGeorge GalaziosNikoleta KoutlakiNikos NikolettosGeorge KoliosPublished in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2021)
In this study, we observed higher levels of sFlt-1 mRNA expression in the placenta of spontaneous abortions, while expression of other growth factors in placenta and decidua remained constant. This suggests that an imbalance of sFlt-1 expression in the placenta might contribute to the pathogenesis of spontaneous abortion, probably via oxidative stress, providing a possible biomarker for prompt identification of this condition.