Long non-coding RNA SLC2A1-AS1 induced by GLI3 promotes aerobic glycolysis and progression in esophageal squamous cell carcinoma by sponging miR-378a-3p to enhance Glut1 expression.

Hongtao LiuQing ZhangYinsen SongYibin HaoYunxia CuiXin ZhangXueying ZhangYue QinGuangzhao ZhuFeng WangJinghan DangShanshan MaYanting ZhangWenna GuoShenglei LiFangxia GuanTianli Fan

Published in: Journal of experimental & clinical cancer research : CR (2021)

SLC2A1-AS1 plays important roles in ESCC development and progression by regulating glycolysis, and SLC2A1-AS1/miR-378a-3p/Glut1 regulatory axis may be a novel therapeutic target in terms of metabolic remodeling of ESCC patients.

Keyphrases

long non coding rna
poor prognosis
end stage renal disease
newly diagnosed
ejection fraction
prognostic factors
peritoneal dialysis
transcription factor
high intensity