Preoperative Multistrain Probiotic Supplementation Does Not Affect Body Weight Changes or Cardiometabolic Risk Factors in Bariatrics: Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Marta PotrykusSylwia Czaja-StolcMarta StankiewiczMichal SzymanskiIgor ŁoniewskiŁukasz KaskaMonika Proczko-StepaniakPublished in: Nutrients (2024)
Emerging evidence suggests that microbiota plays a crucial role in the development, progression, and therapeutic options in obesity and its comorbidities. This study assessed preoperative probiotic therapy's impact on bariatric treatment outcomes. A 12-week randomized, double-blind, placebo-controlled trial with 48 patients undergoing bariatric surgery was conducted. Participants received probiotics-Sanprobi Barrier-which contained nine strains of bacteria: Bifidobacterium bifidum W23, Bifidobacterium lactis W51 and W52, Lactobacillus acidophilus W37, Levilactobacillus brevis W63, Lacticaseibacillus casei W56, Ligilactobacillus salivarius W24, Lactococcus lactis W19, and Lactococcus lactis W58. Primary outcomes included excess body weight loss, body weight loss, and excess body mass index loss, with secondary objectives focusing on metabolic profiles. Surgical treatment of obesity significantly improved anthropometric and metabolic parameters. No significant differences were observed in primary outcomes or in secondary outcomes between groups at any time point post-surgery. Preoperative probiotics administration did not affect clinical outcomes 1, 3, or 6 months following bariatric surgery.
Keyphrases
- double blind
- weight loss
- placebo controlled
- bariatric surgery
- clinical trial
- patients undergoing
- roux en y gastric bypass
- phase iii
- phase ii
- obese patients
- gastric bypass
- study protocol
- glycemic control
- body weight
- body mass index
- weight gain
- risk factors
- phase ii study
- minimally invasive
- open label
- escherichia coli
- metabolic syndrome
- type diabetes
- physical activity
- randomized controlled trial
- high fat diet induced
- coronary artery bypass
- acute coronary syndrome