Upper and Lower Respiratory Mucous Membrane Plasmacytosis with a Cobblestone Appearance: a Case Report.
Masahiro NakamuraTakashi AnzaiAtsushi ArakawaYusuke TakataKenji SonodaErina IshimizuFumihiko MatsumotoPublished in: Ear, nose, & throat journal (2022)
A 53-year-old woman with a recurrent sore throat, xerostomia, nasal obstruction, and nasal discharge came to our hospital. At the first visit, she did not have a fever, but a blood test showed an intense inflammatory response. She had oral mucosal erosion. She developed dyspnea 2 months later. Nasendoscopy, laryngoscopy, and bronchoscopy showed upper and lower respiratory mucosa cobblestone appearance. Microscopy of the nasal and pharyngeal mucosa biopsy found regular mononuclear inflammatory cell dense submucosal infiltrate, mainly plasma cells. A mucous membrane plasmacytosis diagnosis was made. Prednisolone 1 mg/kg/day rapidly improved bronchial symptoms and cobblestone appearance.
Keyphrases
- inflammatory response
- chronic rhinosinusitis
- induced apoptosis
- high resolution
- single cell
- oxidative stress
- cell therapy
- single molecule
- respiratory tract
- high throughput
- emergency department
- optical coherence tomography
- lipopolysaccharide induced
- signaling pathway
- stem cells
- lps induced
- palliative care
- sleep quality
- mass spectrometry
- endoplasmic reticulum stress
- fine needle aspiration
- ulcerative colitis
- advanced cancer
- cell proliferation