Genome-wide CRISPR/Cas9 library screening identified OGDH as a regulator of disease progress and resistance to decitabine in myelodysplastic neoplasm by reprogramming glutamine metabolism.

Xiaoyan XuJiaqian QiHong WangZiyan ZhangTingting PanXueqian LiJingyi YangHaohao HanMengting GuoMeng ZhouChengsen CaiYaqiong TangQixiu HouSuning ChenDepei WuYue Han

Published in: Leukemia (2024)

Keyphrases

crispr cas
acute myeloid leukemia
genome wide
genome editing
dna methylation
bone marrow
low grade
transcription factor
gene expression