Abundant intratumoral fibrosis prevents lymphocyte infiltration into peritoneal metastases of colorectal cancer.
En WangMasatsune ShibutaniHisashi NagaharaTatsunari FukuokaYasuhito IsekiYuki OkazakiShinichiro KashiwagiHiroaki TanakaKiyoshi MaedaKosei HirakawaMasaichi OhiraPublished in: PloS one (2021)
The infiltration of T lymphocytes into tumors is prevented in peritoneal metastases of colorectal cancer due to the high intratumoral fibrosis, which may lead to treatment resistance and a poor prognosis.