TNF-α antagonist attenuates systemic lipopolysaccharide-induced brain white matter injury in neonatal rats.
Seung Han ShinEe Kyung KimKyung-Yup LeeHan-Suk KimPublished in: BMC neuroscience (2019)
It appears that etanercept reduce WMI in the neonatal rat brain via attenuation of systemic and local inflammation. This study provides preclinical data suggesting etanercept-mediated modulation of inflammation as a promising approach to reduce WMI caused by sepsis or necrotizing enterocolitis in preterm infants.
Keyphrases
- lipopolysaccharide induced
- white matter
- rheumatoid arthritis
- preterm infants
- oxidative stress
- inflammatory response
- low birth weight
- ankylosing spondylitis
- rheumatoid arthritis patients
- juvenile idiopathic arthritis
- multiple sclerosis
- intensive care unit
- acute kidney injury
- disease activity
- electronic health record
- big data
- stem cells
- machine learning
- resting state
- mesenchymal stem cells
- drug induced
- subarachnoid hemorrhage
- preterm birth
- bone marrow
- data analysis