Human adipose and synovial-derived MSCs synergistically attenuate osteoarthritis by promoting chondrocyte autophagy through FoxO1 signaling.
Jianqun WuSongqiang HuangYangyi YuQiang LianYang LiuWenfeng DaiQisong LiuYonghao PanGui-Ang LiuKai LiChao LiuGuangheng LiPublished in: Stem cell research & therapy (2024)
A combination of human ADSCs and SDSCs demonstrated higher potential than a single type of stem cell, demonstrating potential as a novel treatment for OA.
Keyphrases
- endothelial cells
- stem cells
- induced pluripotent stem cells
- signaling pathway
- pluripotent stem cells
- rheumatoid arthritis
- mesenchymal stem cells
- cell death
- knee osteoarthritis
- oxidative stress
- transcription factor
- type diabetes
- adipose tissue
- metabolic syndrome
- endoplasmic reticulum stress
- cell proliferation
- climate change
- bone marrow
- pi k akt