Differential expression of CD8 defines phenotypically distinct cytotoxic T cells in cancer and multiple sclerosis.
Tobias BurkardMartina Herrero San JuanCaroline DreisAnastasiia KiprinaDmitry NamgaladzeKai SiebenbrodtSebastian LugerChristian FoerchJosef M PfeilschifterAndreas WeigertHeinfried H RadekePublished in: Clinical and translational medicine (2022)
In summary, our data show that functionally distinct cytotoxic T lymphocytes can be identified based on their expression of CD8. Indicating a more general role in CD8 T cell immunity, these cells may play opposing roles in the TME, and also in the pathophysiology of autoimmune diseases such as multiple sclerosis.