Environmental fungal sensitisation associates with poorer clinical outcomes in COPD.

Pei Yee TiewFanny Wai-San Ko Sze Lei PangSri Anusha MattaYang Yie SioMau Ern PohKenny J X LauMicheál Mac AogáinTavleen Kaur JaggiFransiskus Xaverius IvanNicolas E GaultierAkira UchidaDaniela I Drautz-MosesHuiying XuMariko Siyue KohDavid Shu Cheong HuiAugustine TeeJohn Arputhan AbisheganadenStephan C SchusterFook Tim Chew Sanjay Haresh Chotirmall

Published in: The European respiratory journal (2020)

Fungal sensitisation is prevalent in COPD and associates with frequent exacerbations representing a potential treatable trait. Outdoor and indoor (home) environments represent a key source of fungal allergen exposure, amenable to intervention, in "sensitised" COPD.

Keyphrases

chronic obstructive pulmonary disease
lung function
air pollution
cystic fibrosis
particulate matter
randomized controlled trial
healthcare
human health
gene expression
genome wide
climate change
allergic rhinitis