Ophiocordyceps formosana improves hyperglycemia and depression-like behavior in an STZ-induced diabetic mouse model.
Chao-Wei HuangTzu-Wen HongYing-Jing WangKo-Chien ChenJu-Chun PeiTai-Yuan ChuangWen-Sung LaiSheng-Hong TsaiRichard ChuWei-Cheng ChenLee-Yan SheenSatoru TakahashiShih-Torng DingTang-Long ShenPublished in: BMC complementary and alternative medicine (2016)
Our findings illustrated, for the first time, the medicinal merits of O. formosana on Type I diabetes and hyperglycemia-induced depression. OFE were found to promote the expression of adiponectin, which is an adipokine involved in insulin sensitivity and hold anti-depressive effects. In addition, OFE administration also displayed altered levels of neurotransmitters in certain brain regions that may have contributed to its anti-depressive effect. Collectively, this current study provided insights to the potential therapeutic effects of O. formosana extracts in regards to hyperglycemia and its depressive complications.
Keyphrases
- diabetic rats
- oxidative stress
- mouse model
- bipolar disorder
- type diabetes
- depressive symptoms
- stress induced
- high glucose
- cardiovascular disease
- poor prognosis
- metabolic syndrome
- drug induced
- physical activity
- resting state
- risk assessment
- endothelial cells
- multiple sclerosis
- skeletal muscle
- blood brain barrier
- climate change
- brain injury
- wound healing
- human health