Treatment of osteonecrosis of the femoral head by core decompression and implantation of fully functional ex vivo-expanded bone marrow-derived mesenchymal stem cells: a proof-of-concept study.
Rodrigo MardonesDaniel CamachoFrancisco MonsalvoNicolás ZulchClaudio JofreJosé J MinguellPublished in: Stem cells and cloning : advances and applications (2019)
Outcomes of this study confirmed the safety and effectiveness of the MSC-based therapy used. After a follow-up period (19-54 months), in all patients, the hip function was significantly improved and pain intensity markedly reduced. As a corollary, no patient required hip arthroplasty.
Keyphrases
- bone marrow
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- chronic pain
- randomized controlled trial
- mesenchymal stem cells
- systematic review
- peritoneal dialysis
- prognostic factors
- total hip arthroplasty
- case report
- pain management
- high intensity
- skeletal muscle
- patient reported outcomes
- spinal cord
- insulin resistance
- patient reported
- weight loss
- combination therapy