Vaccine Therapy for Heart Failure Targeting the Inflammatory Cytokine Igfbp7.
Manami KatohSeitaro NomuraShintaro YamadaMasamichi ItoHiroki HayashiMikako KatagiriTuolisi HeryedTakayuki FujiwaraNorifumi TakedaMiyuki NishidaMaki SugayaMiki KatoTsuyoshi OsawaHiroyuki AbeYoshitaka SakuraiToshiyuki KoKanna FujitaBo ZhangSatoshi HatsuseTakanobu YamadaShunsuke InoueZhehao DaiMasayuki KubotaKousuke SawamiMinoru OnoHiroyuki MoritaYoshiaki KubotaSeiya MizunoSatoru TakahashiMakoto NakanishiTetsuo UshikuHironori NakagamiHiroyuki AburataniIssei KomuroPublished in: Circulation (2024)
Igfbp7 produced by senescent ECs causes cardiac dysfunction and vaccine therapy targeting Igfbp7 may be useful to prevent the development of heart failure.