Hepatocyte-specific loss of melanocortin 1 receptor disturbs fatty acid metabolism and promotes adipocyte hypertrophy.

Keshav Thapa Bishwa R Ghimire Kisun PokharelMinying CaiEriika SavontausPetteri Rinne

Published in: International journal of obesity (2005) (2024)

Hepatocyte-specific loss of MC1R disturbs fatty acid metabolism in the liver and leads to an obesity phenotype characterized by enhanced adipocyte hypertrophy and TG accumulation in the liver and circulation.

Keyphrases

fatty acid
insulin resistance
metabolic syndrome
adipose tissue
liver injury
type diabetes
weight loss
weight gain
drug induced
body mass index