Nasopharyngeal Dysbiosis Precedes the Development of Lower Respiratory Tract Infections in Young Infants, a Longitudinal Infant Cohort Study.

Rotem LapidotTyler FaitsArshad IsmailMushal AllamZamantungwak KhumaloWilliam B MacLeod Geoffrey KwendaZachariah MupilaRuth NakazweDaniel SegrèWilliam Evan JohnsonDonald M TheaLawrence Mwananyanda Christopher J Gill

Published in: Gates open research (2024)

Our results suggest that specific characteristics of the NP microbiome precede LRTI in young infants and may be present in their mothers as well. Early dysbiosis may play a role in the causal pathway leading to LRTI or could be a marker of underlying immunological, environmental, or genetic characteristics that predispose to LRTI.

Keyphrases

respiratory tract
middle aged
genome wide
gene expression
copy number
dna methylation