Emerging roles of the long non-coding RNA NEAT1 in gynecologic cancers.
Maryam FarzanehMahrokh Abouali Gale DariAmir AnbiyaieeSajad NajafiDian DayerAbdolah Mousavi SalehiMona KeivanMehri GhafourianShahab UddinShirin AzizidoostPublished in: Journal of cell communication and signaling (2023)
Gynecologic cancers are a worldwide problem among women. Recently, molecular targeted therapy opened up an avenue for cancer diagnosis and treatment. Long non-coding RNAs (lncRNAs) are RNA molecules (> 200 nt) that are not translated into protein, and interact with DNA, RNA, and proteins. LncRNAs were found to play pivotal roles in cancer tumorigenesis and progression. Nuclear paraspeckle assembly transcript 1 (NEAT1) is a lncRNA that mediates cell proliferation, migration, and EMT in gynecologic cancers by targeting several miRNAs/mRNA axes. Therefore, NEAT1 may function as a potent biomarker for the prediction and treatment of breast, ovarian, cervical, and endometrial cancers. In this narrative review, we summarized various NEAT1-related signaling pathways that are critical in gynecologic cancers. Long non-coding RNA (lncRNA) by targeting various signaling pathways involved in its target genes can regulate the occurrence of gynecologic cancers.
Keyphrases
- long non coding rna
- poor prognosis
- endometrial cancer
- cell proliferation
- signaling pathway
- papillary thyroid
- childhood cancer
- epithelial mesenchymal transition
- polycystic ovary syndrome
- genome wide
- pi k akt
- insulin resistance
- genome wide identification
- metabolic syndrome
- binding protein
- young adults
- type diabetes
- dna methylation
- nucleic acid
- transcription factor
- lymph node metastasis
- squamous cell carcinoma
- rna seq
- protein protein
- replacement therapy