HER2/ERBB2 overexpression in advanced gallbladder carcinoma: comprehensive evaluation by immunocytochemistry and fluorescence in situ hybridisation on fine-needle aspiration cytology samples.
Pragya VermaParikshaa GuptaNalini GuptaRadhika SrinivasanPankaj GuptaUsha DuttaShelly SharmaRadha UppalRitambhra NadaAnupam LalPublished in: Journal of clinical pathology (2023)
This is the first study to evaluate the expression of HER2/ERBB2 on cytological aspirates in AGBC using ICC and FISH. HER2/ERBB2 overexpression(20%) was significantly associated with AGBC. Furthermore, predominant papillary or acinar arrangements of tumour cells in the cytological smears were significantly associated with HER2/ERBB2 overexpression. They can serve as potential predictors of HER2/ERBB2 overexpression to select AGBC patients for anti-HER2 targeted therapies.
Keyphrases
- fine needle aspiration
- tyrosine kinase
- ultrasound guided
- cell proliferation
- transcription factor
- end stage renal disease
- induced apoptosis
- poor prognosis
- ejection fraction
- chronic kidney disease
- prognostic factors
- cell cycle arrest
- high grade
- binding protein
- cell death
- patient reported outcomes
- risk assessment
- single molecule