Definition and diagnosis of cerebral palsy in genetic studies: a systematic review.
Ryan PhamBen-Willem J MolJozef GeczAlastair H MacLennanSuzanna C MacLennanMark A CorbettClare L van EykDani L WebberLyle J PalmerJesia G BerryPublished in: Developmental medicine and child neurology (2020)
Limited compliance with international consensus guidelines on phenotypic definition and mediocre reporting of CP case ascertainment hinders the comparison of results among genetic studies of CP (including meta-analyses), thereby limiting the quality, interpretability, and generalizability of study findings. Compliance with the SCPE guidelines is important for ongoing gene discovery efforts in CP, given the potential for misclassification of unrelated neurological conditions as CP.
Keyphrases
- cerebral palsy
- genome wide
- meta analyses
- clinical practice
- copy number
- systematic review
- case control
- small molecule
- quality improvement
- randomized controlled trial
- dna methylation
- emergency department
- high throughput
- risk assessment
- adverse drug
- transcription factor
- human health
- single cell
- drug induced
- brain injury
- genome wide analysis