Cyclosporine modulates neutrophil functions via the SIRT6-HIF-1α-glycolysis axis to alleviate severe ulcerative colitis.

Huiying LuJian LinChunjin XuMingming SunKeqiang ZuoXiaoping ZhangMingsong LiHailiang HuangZhong LiWei WuBaisui FengZhan Ju Liu

Published in: Clinical and translational medicine (2021)

The data reveal a novel mechanism of CsA in alleviating ASUC by promoting neutrophil HIF-1α expression and restricting excessive neutrophil activation in a SIRT6-HIF-1α-glycolysis axis, suggesting SIRT6 as a candidate target for maintaining mucosal homeostasis and treating intestinal inflammation.

Keyphrases

ulcerative colitis
oxidative stress
ischemia reperfusion injury
endothelial cells
poor prognosis
early onset
electronic health record
weight gain
big data
gene expression
physical activity
binding protein
body mass index
dna methylation
weight loss