Radiofluorinated GPC3-Binding Peptides for PET Imaging of Hepatocellular Carcinoma.
Youcai LiJun ZhangJiamei GuKongzhen HuShun HuangPeter S ContiHubing WuKai ChenPublished in: Molecular imaging and biology (2021)
The results demonstrated that Al[18F]F-GP2633 is a promising probe for PET imaging of GPC3 expression in HCC. Convenient preparation, excellent GPC3 specificity in HCC, and favorable excretion profile of Al[18F]F-GP2633 warrant further investigation for clinical translation. PET imaging with a GPC3-specific probe would provide clinicians with vital diagnostic information that could have a significant impact on the management of HCC patients.
Keyphrases
- pet imaging
- positron emission tomography
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- poor prognosis
- living cells
- quantum dots
- healthcare
- prognostic factors
- palliative care
- binding protein
- patient reported outcomes
- high resolution
- health information
- social media
- amino acid
- single molecule
- dna binding
- molecularly imprinted
- patient reported