A randomized clinical trial demonstrating cell type specific effects of hyperlipidemia and hyperinsulinemia on pituitary function.
Rosemary McDonaldKatherine KuhnThy B NguyenAndrew TannousIrene SchauerNanette SantoroAndrew P BradfordPublished in: PloS one (2022)
Acute hyperlipidemia and hyperinsulinemia exerted differential, cell type specific effects on the hypothalamic-pituitary-gonadal, adrenal and thyroid axes. Elucidation of mechanisms underlying the selective modulation of pituitary trophic hormones, in response to changes in diet and metabolism, may facilitate therapeutic intervention in obesity-related neuroendocrine and reproductive dysfunction.
Keyphrases
- growth hormone
- weight loss
- high fat diet induced
- high fat diet
- insulin resistance
- randomized controlled trial
- metabolic syndrome
- liver failure
- type diabetes
- physical activity
- oxidative stress
- drug induced
- respiratory failure
- weight gain
- intensive care unit
- hepatitis b virus
- adipose tissue
- acute respiratory distress syndrome
- mechanical ventilation