BRAFV600E-Driven Lung Adenocarcinoma Requires Copper to Sustain Autophagic Signaling and Processing.

Tiffany TsangXingxing GuCaroline I DavisJessica M PosimoZoey A MillerDonita C Brady

Published in: Molecular cancer research : MCR (2022)

We establish that copper chelation therapy inhibits both autophagy and MAPK signaling in BRAFV600E-driven lung adenocarcinoma, thus overcoming the upregulation of protective autophagy elicited by canonical MAPK pathway inhibitors.

Keyphrases

signaling pathway
cell death
oxidative stress
pi k akt
endoplasmic reticulum stress
cell proliferation
oxide nanoparticles
poor prognosis
mesenchymal stem cells
cell therapy