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BRAFV600E-Driven Lung Adenocarcinoma Requires Copper to Sustain Autophagic Signaling and Processing.

Tiffany TsangXingxing GuCaroline I DavisJessica M PosimoZoey A MillerDonita C Brady
Published in: Molecular cancer research : MCR (2022)
We establish that copper chelation therapy inhibits both autophagy and MAPK signaling in BRAFV600E-driven lung adenocarcinoma, thus overcoming the upregulation of protective autophagy elicited by canonical MAPK pathway inhibitors.
Keyphrases
  • signaling pathway
  • cell death
  • oxidative stress
  • pi k akt
  • endoplasmic reticulum stress
  • cell proliferation
  • oxide nanoparticles
  • poor prognosis
  • mesenchymal stem cells
  • cell therapy