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Role of the CTCF Binding Site in Human T-Cell Leukemia Virus-1 Pathogenesis.

Ancy JosephXiaogang ChengJohn HardingJacob Al-SaleemPatrick GreenDeborah VeisDaniel RauchLee Ratner
Published in: bioRxiv : the preprint server for biology (2024)
, we analyzed a mutant virus lacking the binding site in humanized mice. We found that this mutation slowed virus spread and attenuated the development of disease. Gene expression studies demonstrated a dynamic role of CTCF in regulating viral gene expression and T lymphocyte activation.
Keyphrases
  • gene expression
  • dna methylation
  • endothelial cells
  • acute myeloid leukemia
  • type diabetes
  • wild type
  • peripheral blood
  • metabolic syndrome
  • skeletal muscle
  • monoclonal antibody
  • pluripotent stem cells