Role of the CTCF Binding Site in Human T-Cell Leukemia Virus-1 Pathogenesis.
Ancy JosephXiaogang ChengJohn HardingJacob Al-SaleemPatrick GreenDeborah VeisDaniel RauchLee RatnerPublished in: bioRxiv : the preprint server for biology (2024)
, we analyzed a mutant virus lacking the binding site in humanized mice. We found that this mutation slowed virus spread and attenuated the development of disease. Gene expression studies demonstrated a dynamic role of CTCF in regulating viral gene expression and T lymphocyte activation.