Role of the CTCF Binding Site in Human T-Cell Leukemia Virus-1 Pathogenesis.

Ancy JosephXiaogang ChengJohn HardingJacob Al-SaleemPatrick GreenDeborah VeisDaniel RauchLee Ratner

Published in: bioRxiv : the preprint server for biology (2024)

, we analyzed a mutant virus lacking the binding site in humanized mice. We found that this mutation slowed virus spread and attenuated the development of disease. Gene expression studies demonstrated a dynamic role of CTCF in regulating viral gene expression and T lymphocyte activation.

Keyphrases

gene expression
dna methylation
endothelial cells
acute myeloid leukemia
type diabetes
wild type
peripheral blood
metabolic syndrome
skeletal muscle
monoclonal antibody
pluripotent stem cells