Efficacy and safety of papaverine as an in vitro motility enhancer on human spermatozoa.
Ebru IbisSerhat HaymeEkin BaysalNursel GulSinan ÖzkavukçuPublished in: Journal of assisted reproduction and genetics (2021)
Our results suggest that in vitro papaverine treatment for 30 min adequately improves motility of post-thaw sperm, without leading to acrosome reaction, DNA damage, and viability loss. Theophylline's potency on increasing the ratio of total motile spermatozoa was found significantly superior than the two tested compounds. Prospective clinical studies with embryo production, pregnancy, and live birth data should be undertaken.
Keyphrases
- dna damage
- pregnancy outcomes
- biofilm formation
- endothelial cells
- oxidative stress
- transcription factor
- preterm birth
- electronic health record
- dna repair
- escherichia coli
- binding protein
- machine learning
- combination therapy
- pluripotent stem cells
- pseudomonas aeruginosa
- deep learning
- artificial intelligence
- cystic fibrosis
- candida albicans
- replacement therapy