Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes.

Terri C ThayerAnna E LongRachel J AitkenIsabel V WilsonClare MegsonStephanie J HannaF Susan WongKathleen M Gillespie

Published in: Diabetologia (2021)

We conclude that activated memory CD4+ Tregs from slow progressors are expanded and enriched for GITR expression, highlighting the need for further study of Treg heterogeneity in individuals at risk of developing type 1 diabetes.

Keyphrases

type diabetes
working memory
glycemic control
poor prognosis
cardiovascular disease
insulin resistance
single cell
binding protein
adipose tissue
long non coding rna
skeletal muscle