Ex vivo perfusion of human lymph nodes†.
Qian XuJames E MoorePublished in: The Journal of pathology (2020)
In a recent study published in The Journal of Pathology, Barrow-McGee et al described a feasibility study of a real-time ex vivo perfusion model of the axillary lymph nodes (ALNs) from breast cancer patients for immune-oncological investigations. The study showed that perfused ALNs remain viable for up to 24 h, and perfusion of therapeutic antibodies confirmed the ability to reach ALN-resident cells. This work is a highly encouraging demonstration of feasibility for further research into lymphatic system function, with applications to immune function, vaccinations, and cancer. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Keyphrases
- lymph node
- endothelial cells
- contrast enhanced
- sentinel lymph node
- neoadjuvant chemotherapy
- magnetic resonance imaging
- computed tomography
- randomized controlled trial
- patient safety
- papillary thyroid
- young adults
- magnetic resonance
- early stage
- cell proliferation
- oxidative stress
- cell death
- induced pluripotent stem cells
- robot assisted
- radical prostatectomy
- ultrasound guided
- emergency medicine