Characteristics of HIF-1Α and HSP70 MRNA Expression, Level, and Inter-leukins in Experimental Chronic Generalized Periodontitis.

The administration of Mexidol at a dosage of 250 mg/kg, as well as the combination of Thiotriazoline and L-arginine in a ratio of 1:4 at a dosage of 200 mg/kg, resulted in a significant reduction in gingival pocket depth in animals with CGP. Specifically, the gingival pocket depth was reduced to 6 mm (p<0.05) with Mexidol and further reduced to 4 mm (p<0.05) with the combination of Thiotriazoline and L-arginine. Additionally, the animals exhibited minimal bleed-ing, swelling, and tooth mobility when treated with the combination of Thiotriazoline and L-arginine. The administration of a combination of Thiotriazoline and L-arginine (in a ratio of 1:4) at a dos-age of 200 mg/kg to animals with CGP resulted in a noteworthy reduction in the blood concen-tration of pro-inflammatory cytokines IL-1b and TNF-a. Specifically, there was a significant de-crease of 56.1% (p<0.05) in IL-1b and 71% (p<0.05) in TNF-a levels. The course administration of a combination of Thiotriazoline and L-arginine (1:4) (200 mg/kg) to animals with CGP led to an increased expression of HSP70 mRNA (p<0.05) in the periodon-tium by 8.2 times and HIF-1a mRNA by 8.2 times. 2.8 times (p<0.05) against the background of an increase in the blood concentration of HSP70 by 95% (p<0.05). Also, in the periodontium of animals in this group, a decrease in the expression of c-Fos mRNA by 36.7% (p<0.05) was found compared to the control group.