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Molecular mechanism of MLCK1 inducing 5-Fu resistance in colorectal cancer cells through activation of TNFR2/NF-κB pathway.

Huifeng TangHui ZhouLiang ZhangTingting TangNing Li
Published in: Discover oncology (2024)
MLCK1 high expression can enhance resistance to 5-Fu in colorectal cancer cells and the sensitivity to 5-Fu was increased after knocking down the expression of MLCK1, that might be closely correlated to TNFR2/NF-κB pathway, which will provide a new method for the treatment of colorectal cancer patients who are resistant to 5-Fu chemotherapy.
Keyphrases
  • poor prognosis
  • signaling pathway
  • oxidative stress
  • nuclear factor
  • long non coding rna
  • immune response
  • radiation therapy
  • combination therapy