Cinnamon: an aromatic condiment applicable to chronic kidney disease.
Laís de Souza Gouveia MoreiraIsabela de Souza da Costa BrumDrielly C M de Vargas ReisLiana TrugilhoTuany R ChermutMarta EsgalhadoLudmila F M F CardozoPeter StenvinkelPaul G ShielsDenise MafraPublished in: Kidney research and clinical practice (2023)
Cinnamon, a member of the Lauraceae family, has been widely used as a spice and traditional herbal medicine for centuries and has shown beneficial effects in cardiovascular disease, obesity, and diabetes. However, its effectiveness as a therapeutic intervention for chronic kidney disease (CKD) remains unproven. The bioactive compounds within cinnamon, such as cinnamaldehyde, cinnamic acid, and cinnamate, can mitigate oxidative stress, inflammation, hyperglycemia, gut dysbiosis, and dyslipidemia, which are common complications in patients with CKD. In this narrative review, we assess the mechanisms by which cinnamon may alleviate complications observed in CKD and the possible role of this spice as an additional nutritional strategy for this patient group.
Keyphrases
- chronic kidney disease
- end stage renal disease
- cardiovascular disease
- oxidative stress
- type diabetes
- randomized controlled trial
- diabetic rats
- risk factors
- metabolic syndrome
- insulin resistance
- systematic review
- dna damage
- induced apoptosis
- cardiovascular risk factors
- physical activity
- ischemia reperfusion injury
- amino acid
- cardiovascular events
- weight gain
- skeletal muscle
- body mass index