Visible-Light Enabled C(s p 3 )-C(s p 2 ) Cross-Electrophile Coupling via Synergistic Halogen-Atom Transfer (XAT) and Nickel Catalysis.

Girish Suresh YedaseAvishek Kumar JhaVeera Reddy Yatham

Published in: The Journal of organic chemistry (2022)

We herein report the first visible-light-mediated cross-coupling of unactivated alkyl iodides with aryl bromides through synergistic halogen atom transfer (XAT) and nickel catalysis. This simple protocol operates under mild reaction conditions and tolerates a variety of functional groups affording C(s p 3 )-C(s p 2 ) cross-coupling products in good to moderate yields.

Keyphrases

visible light
electron transfer
cancer therapy
reduced graphene oxide
molecular dynamics
randomized controlled trial
oxide nanoparticles
carbon nanotubes
metal organic framework
high intensity
room temperature
gold nanoparticles
ionic liquid