Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis.

Chuangen LiYong WangDabin LiuChi Chun WongOlabisi Oluwabukola CokerXiang ZhangChangan LiuYunfei ZhouYali LiuWei KangKa Fai ToJoseph Jao Yiu Sung Jun Yu

Published in: Gut (2022)

This study demonstrates that SQLE mediates oncogenesis via cell intrinsic effects and modulation of gut microbiota-metabolite axis. SQLE represents a therapeutic target and prognostic marker in CRC.

Keyphrases

cell proliferation
papillary thyroid
single cell
cell cycle
cell therapy
young adults