Generation of human antibodies targeting human platelet antigen (HPA)-1a.
Janita J OosterhoffFederica LintyRemco VisserThijs de VosSuzanne Hofstede-van EgmondMiranda van de WeerdLeendert PorcelijnMasja de HaasEllen van der SchootGestur VidarssonPublished in: Transfusion (2024)
This study outlined an effective method for the isolation of HPA-1a-specific B-cells and the generation of monoclonal antibodies. Further characterization of these antibodies holds promise for better understanding the pathogenic nature of alloantibodies in FNAIT.