Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus.
Xing-Lou YangBen HuBo WangMei-Niang WangQian ZhangWei ZhangLi-Jun WuXing-Yi GeYun-Zhi ZhangPeter DaszakLin-Fa WangZheng-Li ShiPublished in: Journal of virology (2015)
We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.
Keyphrases
- respiratory syndrome coronavirus
- sars cov
- coronavirus disease
- copy number
- endothelial cells
- single cell
- genome wide
- stem cells
- cell therapy
- induced pluripotent stem cells
- dna methylation
- current status
- mesenchymal stem cells
- bone marrow
- pluripotent stem cells
- transcription factor
- binding protein
- genome wide identification
- case control