The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases.

Akiteru GotoMasamitsu TanakaMakoto YoshidaMichinobu UmakoshiHiroshi NanjoKouya ShiraishiMotonobu SaitoTakashi KohnoSei KuriyamaHayato KonnoKazuhiro ImaiHajime SaitoYoshihiro MinamiyaDaichi Maeda

Published in: PloS one (2017)

This clinicopathological study of 370 NSCLC cases and the cell biological studies of NSCLC cell lines clarified the tumor-suppressive role of miR-451 and its prognostic value. We also validated MIF as a target of miR-451 in NSCLC.

Keyphrases

long non coding rna
cell proliferation
small cell lung cancer
long noncoding rna
poor prognosis
advanced non small cell lung cancer
brain metastases
single cell
cell therapy
epidermal growth factor receptor
mesenchymal stem cells