The epithelial zinc transporter ZIP10 epigenetically regulates human epidermal homeostasis by modulating histone acetyltransferase activity.
B-H BinS-H LeeJ BhinT IriéS KimJ SeoK MishimaT R LeeD HwangT FukadaEun-Gyung ChoPublished in: The British journal of dermatology (2018)
Our study suggests that ZIP10-mediated zinc distribution is crucial for epidermal homeostasis via HATs. Therefore, zinc-dependent epigenetic regulation could provide alternatives to maintaining healthy skin or alleviating disorders with skin barrier defects.