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Effect of risperidone on morphine-induced conditioned place preference and dopamine receptor D2 gene expression in male rat hippocampus.

Zahra Mansouri AraniNasrin HeidariyehGholamreza GhavipanjehMajid LotfiniaHamid Reza Banafshe
Published in: Brain and behavior (2023)
Our results suggest that risperidone (1 mg/kg) reverses the morphine-induced CPP and may reduce the rewarding properties of morphine. It is also demonstrated that risperidone decreases the expression of D2 receptor in rat hippocampus. Therefore, risperidone can be considered potential adjunct therapy in morphine dependence.
Keyphrases
  • gene expression
  • high glucose
  • oxidative stress
  • diabetic rats
  • poor prognosis
  • binding protein
  • drug induced
  • dna methylation
  • endothelial cells
  • cognitive impairment
  • metabolic syndrome
  • risk assessment
  • cell therapy