Stability and heterogeneity in the anti-microbiota reactivity of human milk-derived Immunoglobulin A.

Chelse B Johnson-HenceKathyayini P GopalakrishnaDarren BodkinKara E CoffeyAnsen H P BurrSyed RahmanAli T RaiDarryl A AbbottYelissa A SosaJustin T TometichJishnu Das Timothy W Hand

Published in: bioRxiv : the preprint server for biology (2023)

We analyze the ability of breast milk-derived Immunoglobulin A (IgA) antibodies to bind the infant intestinal microbiota. We discover that each mother secretes into their breast milk a distinct set of IgA antibodies that are stably maintained over time.

Keyphrases

human milk
low birth weight
preterm infants
single cell