Noninvasive longitudinal PET/CT imaging of CAR T cells using PSMA reporter gene.
Xiangming SongYirui ZhangXiaoying LvZhuoshuo XuYu LongYongkang GaiDawei JiangPing LeiXiaoli LanPublished in: European journal of nuclear medicine and molecular imaging (2023)
Ga]Ga-PSMA-617 PET/CT could reliably detect CAR-ΔPSMA T cells in vitro and in vivo in solid tumors, laying the foundation for the monitoring CAR T cell therapy in the future.
Keyphrases
- pet ct
- cell therapy
- induced apoptosis
- positron emission tomography
- stem cells
- high resolution
- mesenchymal stem cells
- cell cycle arrest
- crispr cas
- genome wide
- copy number
- gene expression
- cross sectional
- computed tomography
- endoplasmic reticulum stress
- cell death
- mass spectrometry
- signaling pathway
- oxidative stress
- cell proliferation
- bone marrow
- photodynamic therapy
- pet imaging
- pi k akt