Prognostic impact of PIK3CA protein expression in triple negative breast cancer and its subtypes.

Constanze ElfgenK ReeveL MoskovszkyU GüthV Bjelic-RadisicM FleischC TauschZ Varga

Published in: Journal of cancer research and clinical oncology (2019)

Despite conflicting results in the literature, our study clearly shows a better outcome of PIK3CA-expressing TNBC, independent of TNBC subtypes. PIK3CA expression in TNBC is not associated with specific clinical or diagnostic features. Further molecular studies and meta-analysis are warranted to clarify the prognostic and predictive role of PIK3CA protein expression.

Keyphrases

protein kinase
poor prognosis
systematic review
binding protein
single molecule