Modular Assembly of 2-Aminoaniline Derivatives by Merging Hydroxylamine-Passerini and Hetero-Cope Rearrangement.
Ning YuJing-Fang LvShi-Mei HeKui-Cheng HeWei-Hao ZhengYu-Qiang ZhouKun JiangXi-Chun PanYe WeiPublished in: Organic letters (2024)
A metal-free three-component protocol that combines a hydroxylamine-Passerini reaction and hetero-Cope rearrangement was realized, which enables the modular assembly of a wide range of structurally new and interesting 2-aminoanilines bearing an α-hydroxyamide substructure.
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