Lymphocytic colitis can be transcriptionally divided into channelopathic and inflammatory lymphocytic colitis.
Archana BhardwajAndreas MünchJulia MontagueStefan KochPhilip C RosenstielCelia Escudero-HernándezPublished in: United European gastroenterology journal (2024)
We conclude that LC can be subdivided into channelopathic LC and inflammatory LC that could be pathomechanistically distinct subtypes despite their shared clinical presentation. Inflammatory LC exhibits a dampened immune response compared to CC and classic IBDs. Our results point to regulatory micro-RNAs as a potential disease-specific feature that may be amenable to therapeutic intervention.
Keyphrases
- simultaneous determination
- immune response
- oxidative stress
- randomized controlled trial
- mass spectrometry
- liquid chromatography
- machine learning
- transcription factor
- ulcerative colitis
- dendritic cells
- high resolution mass spectrometry
- high resolution
- toll like receptor
- tandem mass spectrometry
- inflammatory response
- climate change