Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma.

Kenneth R GundleGary B DeutschHoward J GoodmanSeth M PollackMatthew J ThompsonJessica L DavisMee-Young LeeDaniel C RamirezWilliam KerwinJessica A BertoutMarc O GrenleyKimberly H W SotteroEmily BeirneJason FrazierJoyoti DeyMicah EllisonRichard A KlinghofferRobert G Maki

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

These results are an advance toward use of CIVO as a translational research tool for early evaluation of investigational agents and drug combinations in a novel approach to phase 0 trials.See related commentary by Sleijfer and Lolkema, p. 3897.

Keyphrases

single cell
randomized controlled trial
drug induced
emergency department
clinical trial