Transcriptome Deconvolution Reveals Absence of Cancer Cell Expression Signature in Immune Checkpoint Blockade Response.

Yu Amanda Guo Tanmay Kulshrestha Mei Mei Chang Irfahan Kassam Egor Revkov Simone Rizzetto Aaron C Tan Daniel Shao-Weng Tan Iain Beehuat Tan Anders Jacobsen Skanderup

Published in: Cancer research communications (2024)

Our results challenge the prevailing dogma that cancer cells present tissue-agnostic molecular markers that modulate immune activity and ICB response, which has implications on the development of improved ICB diagnostics and treatments.

Keyphrases

poor prognosis
gene expression
single cell
long non coding rna