Immune Cell Infiltration and the Expression of PD-1 and PD-L1 in Primary PDGFRA-Mutant Gastrointestinal Stromal Tumors.

Xiangfei SunJianyi SunWei YuanXiaodong GaoMin FuAnwei XueHe LiPing ShuYong FangYingyong HouKuntang ShenYihong SunJing QinXinyu Qin

Published in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (2020)

There were abundant infiltrating immune cells in PDGFRA-mutant GISTs. PD-L1 expression was negatively associated with tumor size. The immunotherapy targeting PD-1/PD-L1 checkpoint and IDO may be valuable.

Keyphrases

wild type
poor prognosis
dna damage
cancer therapy
cell proliferation