Production of biologically active human factor IX-Fc fusion protein in the milk of transgenic mice.
Hong YanXiuli GongMiao XuXinbing GuoYanwen ChenYan XueYitao ZengFanyi ZengPublished in: Biotechnology letters (2020)
It is feasible to produce biologically functional FIX-Fc in the mammary gland of transgenic mice. Our preliminary results provide a foundation for the potential scale-up production of FIX-Fc in the milk of dairy animals.