An inhibitor of Krüppel-like factor 5 suppresses peritoneal fibrosis in mice.

Kumiko MutaYuka NakazawaYoko ObataHiro InoueKenta TorigoeMasayuki NakazawaKatsushige AbeAkira FurusuMasanobu MiyazakiKazuo YamamotoTakehiko KojiTomoya Nishino

Published in: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis (2021)

These results indicate the involvement of KLF5 in the progression of experimental peritoneal fibrosis and suggest that Am80 may be potentially useful for the prevention of peritoneal fibrosis through inhibition of KLF5 expression.

Keyphrases

poor prognosis
transcription factor
signaling pathway
metabolic syndrome
binding protein